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Transgender MtF – brain differences. June 29, 2009

Posted by Geekgirl in brain.

Researchers at UCLA School of Medicine study the volume of gray matter in the brains of MtF transgender folks and compare it to straight men and straight women’s brains, using magnetic resonance imaging (MRI). A difference was found in the region of the brain called the putamen. The main function of the putamen is to regulate movements and influence various types of learning. It employs dopamine to perform its functions.

Neuroimage. 2009 Jul 15;46(4):904-7. Epub 2009 Mar 31.

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Regional gray matter variation in male-to-female transsexualism.

Luders ESánchez FJGaser CToga AWNarr KLHamilton LSVilain E.

Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-7334, USA.

Gender identity-one’s sense of being a man or a woman-is a fundamental perception experienced by all individuals that extends beyond biological sex. Yet, what contributes to our sense of gender remains uncertain.

Since individuals who identify as transsexual report strong feelings of being the opposite sex and a belief that their sexual characteristics do not reflect their true gender, they constitute an invaluable model to understand the biological underpinnings of gender identity.

We analyzed MRI data of 24 male-to-female (MTF) transsexuals not yet treated with cross-sex hormones in order to determine whether gray matter volumes in MTF transsexuals more closely resemble people who share their biological sex (30 control men), or people who share their gender identity (30 control women).

Results revealed that regional gray matter variation in MTF transsexuals is more similar to the pattern found in men than in women.

However, MTF transsexuals show a significantly larger volume of regional gray matter in the right putamen compared to men. These findings provide new evidence that transsexualism is associated with distinct cerebral pattern, which supports the assumption that brain anatomy plays a role in gender identity



1. kindle walker - April 1, 2013

so it is possible for myself(MTF, male-to-female) to have a brain of te opposite sex. Yes my brain is that of a males, only in the sense that it pertains to my body which is male. My brain may be somewhat genetically male also, however ths means thatt my brain actually functions as a female brain. During developement in the womb, all brains have the capasity to go either way, male or female, my brain did not masculinize through developement and further growing(life in general), thus it continued to develope just as a female brain(as do females who are non transgender). So really my brain is literally that of a females just inside of a male anatomy. My body has even developed as a females, the only difference is that i get a five o’clock shadow and i have male genetalia. otherwise i make a perfectly functioning female human being and live my life as so literally with out trying.

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