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Presto Chango. Now you are gay. August 21, 2009

Posted by Geekgirl in genetics, sexual orientation.
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It has actually been known for several years now that fruit flies, commonly used for genetic research, can be made gay by turning on or off certain genes. In this case, just one gene. Are fruit flies human? No. But it is still proof that sexual orientation has a biological basis. A summary of how this actually works can be found below. The links are to two articles describing the research, including an interview with Dr. Francuch. The author of the article asks the question would someone develop a drug that could be used to turn sexual orientation on or off; and the ethical implications. You’ll notice that most reader’s comments are from gays who find this idea repulsive. I agree. But one astute reader acknowledges that this evidence that being gay has a biological origin should be welcomed and used to quiet all those people who think it is a choice.

Maybe they should develop the drug. One that turns people gay. Give it to the non-believers so they can wake up and repent for their discrimination. After all, it would certainly be the epitome of walking in a gay person’s shoes.

In fruit flies, homosexuality is biological but not hard-wired

Turning Heterosexuality On and Off – Part 1

Turning Heterosexuality On and Off – Part 2

Public release date: 9-Dec-2007
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Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago

While the biological basis for homosexuality remains a mystery, a team of neurobiologists reports they may have closed in on an answer — by a nose.

The team led by University of Illinois at Chicago researcher David Featherstone has discovered that sexual orientation in fruit flies is controlled by a previously unknown regulator of synapse strength. Armed with this knowledge, the researchers found they were able to use either genetic manipulation or drugs to turn the flies’ homosexual behavior on and off within hours.

Featherstone, associate professor of biological sciences at UIC, and his coworkers discovered a gene in fruit flies they called “genderblind,” or GB. A mutation in GB turns flies bisexual.

Featherstone found the gene interesting initially because it has the unusual ability to transport the neurotransmitter glutamate out of glial cells — cells that support and nourish nerve cells but do not fire like neurons do. Previous work from his laboratory showed that changing the amount of glutamate outside cells can change the strength of nerve cell junctions, or synapses, which play a key role in human and animal behavior.

But the GB gene became even more interesting when post-doctoral researcher Yael Grosjean noticed that all the GB mutant male flies were courting other males.

“It was very dramatic,” said Featherstone. “The GB mutant males treated other males exactly the same way normal male flies would treat a female. They even attempted copulation.”

Other genes that alter sexual orientation have been described, but most just control whether the brain develops as genetically male or female. It’s still unknown why a male brain chooses to do male things and a female brain does female things. The discovery of GB provided an opportunity to understand why males choose to mate with females.

“Based on our previous work, we reasoned that GB mutants might show homosexual behavior because their glutamatergic synapses were altered in some way,” said Featherstone. Specifically, the GB mutant synapses might be stronger.

“Homosexual courtship might be sort of an ‘overreaction’ to sexual stimuli,” he explained.

To test this, he and his colleagues genetically altered synapse strength independent of GB, and also fed the flies drugs that can alter synapse strength. As predicted, they were able to turn fly homosexuality on and off — and within hours.

“It was amazing. I never thought we’d be able to do that sort of thing, because sexual orientation is supposed to be hard-wired,” he said. “This fundamentally changes how we think about this behavior.”

Featherstone and his colleagues reasoned that adult fly brains have dual-track sensory circuits, one that triggers heterosexual behavior, the other homosexual. When GB suppresses glutamatergic synapses, the homosexual circuit is blocked.

Further work showed precisely how this happens — without GB to suppress synapse strength, the flies no longer interpreted smells the same way.

“Pheromones are powerful sexual stimuli,” Featherstone said. “As it turns out, the GB mutant flies were perceiving pheromones differently. Specifically, the GB mutant males were no longer recognizing male pheromones as a repulsive stimulus.”

Featherstone says it may someday be possible to domesticate insects such as fruit flies and manipulate their sense of smell to turn them into useful pollinators rather than costly pests.

###

The research appeared on line today in Nature Neuroscience, and is scheduled for print in the January issue.

Grosjean, now with the Center of Integrative Genomics in Lausanne, Switzerland, is the paper’s first author. Along with Featherstone, authors include Hrvoje Augustin of UIC and Micheline Grillet and Jean-Francois Ferveur of the Université de Bourgogne in Dijon, France.


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